Name: FKBPL Polyclonal Antibody
Price: 253.00 USD

Overview
- Gene Accession: BC004168
  
  Please contact us at for specific academic pricing.
  
  Background
  
  FKBPL,also named as DIR1,NG7 and WISp39,has similarity to the immunophilin protein family,which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is thought to have a potential role in the induced radioresistance,probably by increasing the rate of DNA repair in cells exposed to X rays. Also it appears to have some involvement in general stress response in the control of the cell cycle. It regulates p21 protein stability by binding to Hsp90 and p21. Breast cancer cells stably overexpressing FKBPL became dependent on estrogen for their growth and were dramatically more sensitive to the antiestrogens tamoxifen and fulvestrant,whereas FKBPL knockdown reverses this phenotype. FKBPL is an estrogen-inducible gene that acts as a cochaperone in ERα/Hsp90 molecular complexes; furthermore,FKBPL levels may be both a prognostic indicator and determinant of response to endocrine therapy.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Fusion protein of human FKBPL
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1.3 mg/mL
  
  Antigen
  
  DIR1, FK506 binding protein like, FK506-binding protein-like, Fkbpl, FKBPL, NG7, OTTHUMP00000029170, WAF 1/CIP1 stabilizing protein 39, WAF-1/CIP1 stabilizing protein 39, WISP39 (UniProt:Q9UIM3)
  
  * For reference only.