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Overview
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Reactivity & Specifity: CD5 is present on all mature T cells and most thymocytes. It is also expressed on a small subpopulation of normal B cells. The majority of T- cell malignancies (76%) express CD5, and almost 85% of T- cell acute lymphoblastic leukaemias are CD5 positive. The reactivity of A3-B1 MoAb is directed against the CD19- antigen (B4-antigen), which is expressed on human B lymphocytes. The monoclonal antibody is B lineage-specific and reacts with early B-cell precursors, pre-pre-B-cells, pre-B- cells, B-cells, intermediate B-cells, mature B-cells and some plasmacytoid cells. Plasma cells were found to be negative. The monoclonal antibody does not react with other haemopoïetic cells.. Clinical Application: Further, CD5 is expressed in some B- cell derived lymphoproliferative disorders, notably chronic lymphocytic leukaemia (CLL) (> 90%) (1, 2), and centrocytic leukaemia. CD19 monoclonal antibody also reacts with pre-B-cell- lines, B lymphoblastoid cell-lines and Burkitt cell- lines, and with 50% of myeloma cell-lines. Virtually all non T-ALL, B-CLL and B-cell lymphomas were found to be positive, myeloma cells were found to be negative. This product can be used for evaluation of residual disease in B-cell chronic lymphocytic leukemia patients and bone-marrow remission.
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