FITC/ PE - anti Human CD3/CD8 - 33-2A3, 143-44

FITC/ PE - anti Human CD3/CD8 - 33-2A3, 143-44

Catalog Number:
A001109219IMM
Mfr. No.:
3F18PE1-50T
Price:
$516
  • Size:
    50 test
    Quantity:
    Add to Cart:
      • Overview
        • Reactivity: The CD3 monoclonal antibody is directed against the CD3- antigen (T3-antigen), which is expressed on human T lymphocytes. The monoclonal antibody reacts with 80-90% human peripheral T lymphocytes and medullary thymocytes. The monoclonal antibody does not react with B-cells, monocytes, granulocytes and platelets. The monoclonal antibody is mitogenic for resting T lymphocytes and it blocks the cytolytic activity of CTL clones. The CD8 monoclonal antibody is directed against the CD8-antigen (T8-antigen),which is expressed on human T lymphocytes. The monoclonal antibody reacts with 20-30% of human peripheral T lymphocytes. The monoclonal antibody reacts with T lymphocytes with suppressor-cell activity in pokeweed mitogen- stimulated immunoglobulin production, as was shown in separation experiments (i.e. "panning"). The monoclonal antiody does not react with B-cells, monocytes, granulocytes and platelets. Specificity: The CD3 antibody recognizes 22/26/30 kD MW lymphocyte surface molecules associated with the T cell antigen receptor complex. Reacts with 85% of peripheral blood T lymphocytes, 70% of thymocytes, the majority of T cell chronic lymphocytic leukaemias, Sezary leukaemias and approximately 70% of acute lymphoblastic leukaemias of T cell origin. The CD8 antibody recognizes 30/32 kD MW lymphocyte surface antigen identified by monoclonal antibodies belonging to the CD8 cluster on a sub-population of peripheral blood T lymphocytes, 60% of thymocytes, and a limited number of malignancies of T cell origin. Normal B lymphocytes, monocytes or granulocytes do not express surface CD8 antigen.

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      • Properties
        • Antibody Type
          monoclonal
          Isotype
          IgG2a; IgG1
          Reactivity
          human
          Clone
          33-2A3, 143-44
          Conjugate
          FITC; PE
          Regulatory Status
          CE Marking

          * For research use only.

      • Applications
        • Application
          Flow Cytometry

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