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Overview
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This antibody reacts with the CD62L-antigen, which mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes and promotes initial tethering and rolling of leukocytes in endothelia. The epitope is expressed at high density on the majority of CD45RA-positive and CD45RO-positive peripheral blood T cells (60-70%) and on a subset of thymocytes that includes the multinegative CD3-negative, CD4-negative, and CD8-negative progenitor cells and the CD45RO-negative presumptive thymic generative lineage. It appears at reduced density and frequency on CD45RA-negative thymocytes, comprised mainly of death-committed cells. The antibody also labels a major subset of peripheral blood B cells and thymic B cells.
The antigen is expressed on neutrophils, monocytes, T and B lymphocyte subsets and NK cells. CD62L on neutrophils, but not on lymphocytes, carries the carbohydrate structure sialyl-Lewis X. This carbohydrate is ligand for the selectins P-selectin (CD62P) and E-selectin (CD62E) which can be expressed on endothelial cells, and the interaction of CD62L with these selectins has been argued to play a role in the initial adhesion of neutrophils to endothelium.Please contact us at for specific academic pricing.
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