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Overview
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This antibody reacts with the CD53-antigen, a glycoprotein of 24 kDa belonging to the tetraspanin familiy. CD53 is expressed by all leucocytes, but is absent from erythrocytes and platelets. A number of eukaryotic cell surface antigens have been shown to be related, including mammalian leukocyte antigen CD37, mammalian lysosomal membrane protein CD63, human tumour-associated antigen CD-029, and several others. These proteins are all type II membrane proteins and contain an N-terminal transmembrane (TM) domain, which acts both as a signal sequence and a membrane anchor, and 3 additional TM regions (hence the name `TM4'). The sequences contain a number of conserved cysteine residues.
CD53 may play an important role in thymopoiesis and leukocyte signal transduction and positive selection of thymocytes.Please contact us at for specific academic pricing.
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