FITC - anti Human BCL2 - 124

FITC - anti Human BCL2 - 124

Catalog Number:
A001108812IMM
Mfr. No.:
BCL2F-100T
Price:
$650
  • Size:
    100 test
    Quantity:
    Add to Cart:
      • Overview
        • The 1D11 monoclonal antibody reacts with the human NKG2D, a 42 kDa lectin-like molecule expressed by NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.

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      • Properties
        • Antibody Type
          monoclonal
          Isotype
          IgG1
          Reactivity
          human
          Clone
          124
          Immunogen
          Synthetic peptide comprising amino acids 41-54 of human BCL2 oncoprotein
          Conjugate
          FITC
          Storage
          Store in the dark at 2-8 °C
          Concentration
          Please refer to the Certificate of Analysis for the lot-specific concentration.
          Regulatory Status
          RUO
          Antigen
          NKG2D

          * For research use only.

      • Applications
        • Application Description
          CD314, clone1D11, is a mAb intended for the identification of NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.

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