Name: EXOSC4 Polyclonal Antibody (0.84 mg/mL) for WB, IHC, ELISA
Price: 253.00 USD

Overview
- Calculated MW: 26 kDa
  Observed MW: Refer to figures
  Gene Accession: BC002777
  
  Please contact us at for specific academic pricing.
  
  Background
  
  Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Fusion protein of human EXOSC4
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  0.84 mg/mL
  
  Antigen
  
  EXOSC 4, Exosome complex component RRP41, Exosome complex exonuclease RRP41, Exosome component 4 , Exosome component Rrp41 , FLJ20591 , hRrp41p, p12A , Ribosomal RNA processing protein 41, RRP 41, RRP41, RRP41A , Rrp41p , SKI 6, SKI6 , Ski6p (UniProt:Q9NPD3)
  
  * For reference only.

Applications

Application

WB; IHC; ELISA

Application	Dilutions
WB	1:500-1:2000
IHC	1:50-1:200
ELISA	1:5000-1:10000

EXOSC4 Polyclonal Antibody (0.84 mg/mL) for WB, IHC, ELISA

EXOSC4 Polyclonal Antibody (0.84 mg/mL) for WB, IHC, ELISA

Background

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