ETA ( IHC-grade ), Endothelin Receptor A Polyclonal Antibody

Overview
- The ETA receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human endothelin receptor A. It can be used to detect ETA receptors in Western blots in a phosphorylation-sensitive manner phosphorylation. After agonist activation, ETA is phosphorylated at the carboxyl-terminus. Because the ETA antibody detects the same epitope, it no longer binds to the receptor. It detects selectively ETA receptors that have been hot activated and not phosphorylated. The ETA antibody can also be used to isolate and enrich ETA receptors from cell and tissue lysates. It also detects ETA in cultured cells and tissue sections by immunohistochemistry.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  A synthetic peptide with sequence KNHDQNNHNTDRSSHKDSMN corresponds to amino acids 408-427 in human, mouse and rat ETA
  
  Purification
  
  Antigen affinity chromatography
  
  Formulation
  
  Liquid
  
  Storage
  
  Short-term storage at 4°C and long-term storage at -20°C
  
  Antigen
  
  ETA, EDNRA, Endothelin Receptor A (UniProt:P25101 (human), Q61614 (mouse), P26684 (rat))
  
  * This product is intended for research use only.

Applications

Reference
- Lupp A, Mann A, Heeb A, Kaemmerer D, Sänger J, Evert M, Evert K, Mawrin C, Schulz S. Reassessment of endothelin receptor A expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-8. Peptides. 2015 Apr;66:19-25. doi: 10.1016/j.peptides.2015.02.005. Epub 2015 Feb 20. PubMed PMID: 25708416.