ERK 1/2 Polyclonal Antibody (1 mg/mL) for WB, IHC-P, ELISA

ERK 1/2 Polyclonal Antibody (1 mg/mL) for WB, IHC-P, ELISA

Catalog Number:
A001507644RED
Mfr. No.:
RD231373A
Price:
$253
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      • Overview
        • Calculated MW: 43 kDa
          Observed MW: 44+42 kDa

          Please contact us at for specific academic pricing.

          Background

          Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          Synthesized peptide derived from human ERK 1/2 around the non-phosphorylation site of Tyr204.
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          1 mg/mL
          Antigen
          MAPK3, ERK1, PRKM3, Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p (UniProt:P27361,P28482)

          * For reference only.

      • Applications
        • Application
          WB; IHC-P; ELISA
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:100-1:300
          ELISA 1:10000

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