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Overview
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Background
Eps8L2 (epidermal growth factor receptor kinase substrate 8-like protein 2), also known as EPS8R2 or PP13181, is a 715 amino acid protein that localizes to the cytoplasm and belongs to the Eps8 (epidermal growth factor receptor pathway substrate 8) family. Expressed in placenta and fibroblasts, Eps8L2 functions to stimulate the guanine exchange activity of Sos 1 (son of sevenless homolog 1), a protein that promotes the exchange of Ras-bound GDP for GTP. Additionally, Eps8L2 is thought to associate with Actin and, via this association, may play a role in membrane ruffling and remodeling of the Actin cytoskeleton. Through its ability to regulate protein activation and cytoskeleton dynamics, Eps8L2 may participate in cell growth and differentiation events within the cell. Eps8L2, a protein that is expressed as two isoforms due to alternative splicing, contains one PID (phosphotyrosine interaction) domain and one SH3 domain.
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