DOK3 Polyclonal Antibody

DOK3 Polyclonal Antibody

Catalog Number:
A001507853RED
Mfr. No.:
RD252149A
Price:
$253
  • Size:
    Quantity:
    Add to Cart:
      • Overview
        • Calculated MW: 53 kDa
          Observed MW: Refer to figures
          Gene Accession: BC004564

          Please contact us at for specific academic pricing.

          Background

          DOK3 gene maps to chromosome 5q35.3. Dok3 was tyrosine phosphorylated by Src family members Lck, Fyn, and Lyn. Immunoprecipitation studies showed that Dok3 bound inhibitors SHIP and Csk but did not bind RasGAP. Dok3 binding to SHIP occurred via the SH2 domain. Dok3 also bound Csk via the Csk SH2 domain with possible involvement of the Csk SH3 domain as well.DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human
          Immunogen
          Fusion protein of human DOK3
          Purification
          Antigen affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          0.4 mg/mL
          Antigen
          Docking protein 3, DOK 3, DOK Like Protein, Dok3, DOK3, DOKL Pending, Downstream of tyrosine kinase 3, p62 DOK Like Protein (UniProt:Q7L591)

          * For reference only.

      • Applications
        • Application
          WB; ELISA
        • Application Dilutions
          WB 1:500-1:2000
          ELISA 1:1000-1:5000

    Note: If you don't receive our verification email, do the following:

    Copyright © Amerigo Scientific. All rights reserved.