Name: Denosumab Biosimilar - Research Grade, Low Endotoxin
Price: 560.00 USD

- Overview
  - Specificity: Detects human RANK Ligand. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Denosumab.
    Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
    Isotype Control: Bulk Human IgG2 Isotype Control (IB2) [ICH2255]
    Endotoxin: ≤ 0.75 EU/mg as determined by the LAL method
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Denosumab biosimilar is a human IgG2 monoclonal antibody that binds to human RANKL. Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.
- Properties
  - Host
    
    humanized
    
    Isotype
    
    IgG2
    
    Reactivity
    
    human
    
    Purification
    
    >95% by SDS-PAGE and HPLC
    
    Formulation
    
    Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.
    
    Storage
    
    Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
    
    Molecular Weight
    
    1.0 - 5.0 mg/ml
    
    Antigen
    
    (Gene ID:Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, CD254, Rank Ligang)
    
    * Products are for research use only. Not for use in diagnostic or therapeutic procedures.
- Reference
  - RANKL neutralisation prevents
    osteoclast activation in a human in vitro
    ameloblastoma-bone model

Denosumab Biosimilar - Research Grade, Low Endotoxin

Denosumab Biosimilar - Research Grade, Low Endotoxin

Background

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