Name: CyFlow™ CD86 Low Endotoxin
Price: 324.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    CD86 (B7-2) and CD80 (B7-1) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CD152 (CTLA-4). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
- Properties
  - Host
    
    rat
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG2a
    
    Reactivity
    
    mouse
    
    Clone
    
    GL-1
    
    Immunogen
    
    LPS-activated CBA/Cs mouse splenic B cells
    
    Conjugate
    
    Low Endotoxin
    
    Formulation
    
    The reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
    
    Storage
    
    Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
    
    Concentration
    
    1 mg/mL
    
    Regulatory Status
    
    RUO
    
    Antigen
    
    B7-2, B70
    
    * Research use only
- Applications
  - Application
    
    Flow Cytometry; Functional Assays; Immunocytochemistry; IHC (frozen); Immunoprecipitation