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Overview
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Please contact us at for specific academic pricing.
Background
CD300e (IREM-2; immune receptor expressed by myeloid cells 2, CLM2 or LMIR6) is a monomeric transmembrane glycoprotein with a single extracellular immunoglobulin-like domain. Intracellularly it associates with DAP-12, an ITAM-containing adaptor molecule. CD300e is expressed on mature monocytes and peripheral blood myeloid dendritic cells. Its crosslinking leads to release of pro-inflammatory cytokines, and increased expression of activation markers.
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