Name: CyFlow™ CD271 Biotin
Price: 378.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    CD271 (NGFR, p75NGFR, p75NTR) is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.
- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1
    
    Reactivity
    
    cat; ferret; human; non-human primates; rabbit
    
    Clone
    
    NGFR5
    
    Immunogen
    
    Purified CD271 protein isolated from human melanoma cell line A875
    
    Conjugate
    
    Biotin
    
    Formulation
    
    The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
    
    Storage
    
    Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
    
    Concentration
    
    1 mg/mL
    
    Regulatory Status
    
    RUO
    
    Antigen
    
    LNGFR, NGFr(p75) , NTR, p75(NTR), TNFRSF16
    
    * Research use only
- Applications
  - Application
    
    Flow Cytometry
    
    Application Description
    
    The reagent is designed for indirect immunofluorescence analysis by Flow Cytometry. Suggested working usage is 5·µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.