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Overview
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CRKL encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
PRODUCT INFORMATION
Antigen Species: Human
NCBI Accession No: NP_005198.1
RNA Reference Number: NM_005207.3
OMIM Number: 602007
Chromosome Location: 22q11.21
cDNA size: 912bp
Vector description: This shuttle vector contains the complete ORF. It is inseted Nde I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.Please contact us at for specific academic pricing.
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