Name: Colivelin
Price: 431.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Colivelin is a brain-penetrant neuroprotective peptide, exhibiting potent long-term capacity against Aβ deposition, synaptic plasticity deficits, and neuronal apoptosis in neurodegenerative disease. Moreover, Colivelin is an activator of STAT3, which can rescue ischemic neuronal death and axonal remodeling by activating JAK/STAT3 signaling. Thus, Colivelin has the potential for the treatment of Alzheimer’s disease and ischemic brain injury.
    
    1. Zhao H, Feng Y, Wei C, et al. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway. Neuroscience, 2019, 416: 198-206.
    2. Chiba T, Yamada M, Hashimoto Y, et al. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. The Journal of Neuroscience, 2005, 25(44): 10252-10261.
- Properties
  - Categories
    
    A neuroprotective peptide and activator of STAT3
    
    CAS Number
    
    867021-83-8
    
    Molecular Formula
    
    C119H206N32O35
    
    Molecular Weight
    
    2645.13
    
    Appearance
    
    White lyophilised solid
    
    Purity
    
    Purity ≥ 95.00%
    
    Solubility
    
    insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC[[email protected]]([[email protected]@](/N=C(O)/[[email protected]](/N=C(O)/C/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/C/N=C(O)/[[email protected]](/N=C(O)/[[email protected]]1([H])CCCN1C([[email protected]](/N=C(O)/[[email protected]]2([H])CCCN2C([[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Colivelin

Colivelin

Background

Documents

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