Cleaved-CASP4 p20 (Q81) Polyclonal Antibody

Cleaved-CASP4 p20 (Q81) Polyclonal Antibody

Catalog Number:
A001507632RED
Mfr. No.:
RD230021A
Price:
$253
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      • Overview
        • Calculated MW: 43 kDa
          Observed MW: 43+22 kDa

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          Background

          This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human
          Immunogen
          Synthesized peptide derived from the Internal region of human Caspase-4 p20
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          1 mg/mL
          Antigen
          Apoptotic cysteine protease Mih1/TX, CASP-4, CASP4, CASP4, Caspase 4 apoptosis related cysteine peptidase, Caspase-4 subunit 2, Caspase4, ICE(rel)-II, ICE(rel)II, ICEREL II, ICH2, Mih1/TX, Protease ICH-2, Protease TX, TX (UniProt:P49662)

          * For reference only.

      • Applications
        • Application
          WB; IHC-P; ELISA
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:100-1:300
          ELISA 1:40000

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