Name: Ciclesonide
Price: 204.00 USD

- Overview
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    Background
    
    Ciclesonide is a prodrug of the potent glucocorticoid receptor agonist desisobutyryl-ciclesonide. Ciclesonide undergoes the hydrolysis process by ester cleavage at the C21 position to desisobutyryl-ciclesonide, followed by reversible formation of fatty acid esters in lung cells. Although both ciclesonide and desisobutyryl-ciclesonide are able to bind to the glucocorticoid receptor, the active metabolite desisobutyryl-ciclesonide (IC50 = 210 nM) is about 100-fold more potent than the parent compound ciclesonide (IC50 = 1.75 nM). Formulations containing ciclesonide have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
    
    1. Derendorf H, Nave R, Drollmann A, et al. Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma. European Respiratory Journal, 2006, 28(5): 1042-1050.
    2. Mutch E, Nave R, McCracken N, et al. The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue. Biochemical Pharmacology, 2007, 73(10): 1657-1664.
    3. Belvisi MG, Bundschuh DS, Stoeck M, et al. Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma. Journal of Pharmacology and Experimental Therapeutics, 2005, 314(2): 568-574.
- Properties
  - Categories
    
    A glucocorticoid
    
    Alternative Name
    
    2-((6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-cyclohexyl-7-hydroxy-6a,8a-dimethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl isobutyrate
    
    CAS Number
    
    126544-47-6
    
    Molecular Formula
    
    C32H44O7
    
    Molecular Weight
    
    540.69
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥15.8 mg/mL in DMSO; ≥50.6 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C(OCC([[email protected]@]12[[email protected]@](O[[email protected]@](O2)([H])C3CCCCC3)([H])C[[email protected]@]4([H])[[email protected]]([[email protected]]5([H])[[email protected]](O)([H])C[[email protected]@]41C)([H])CCC6=CC(C=C[[email protected]@]65C)=O)=O)=O)C
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Ciclesonide

Ciclesonide

Background

Documents

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