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Overview
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Calculated MW: 28kDa/30kDa/33kDa/44kDa/46kDa/47kDa
Observed MW: 48kDaPlease contact us at for specific academic pricing.
Background
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described.
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