Overview

The most important challenge in RNA technology is the stability of the chemically synthesized siRNAs. The primary goal of our chemical synthesis technologies is to create chemically modified RNA products that are highly stable and efficiently transfected with our special RNAi-mate transfection reagent so that you can achieve the best result for your particular experiment, especially in mammalian and human cell lines. Our chemically modified RNA oligomers are characterized by:
- Highly efficient transfection
- Highly efficient target gene knockdown
- High specificity for the target gene(s)
- High stability in serum and medium
- Minimized off-target gene knockdown or other side effects

	Standard unmodified siRNA	Chemically modified siRNA
siRNA degradation	Easily degraded in transfected cells.	Very stable and highly nuclease degradation-resistant in serum and transfected cells, without losing gene silencing capacity.
Duration of gene silencing	Relatively short time silencing effect, under normal circumstances approximately one week.	Long time silencing effect, roughly twice that of standard siRNA.
*In vivo* suitability	Due to its poor stability, usually not suitable for in vivo experiments. However, it is effective in most in vitro experiments.	Due to its stability and longevity, the best choice for both in vitro and in vivo studies.

Please contact us at for specific academic pricing.

Properties
- Other Properties
  
  Purification: HPLC
  
  * For research use only.

Chemically-modified siRNA