CCS cDNA

- Overview
  - CCS is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system.
    
    PRODUCT INFORMATION
    Antigen Species: Human
    NCBI Accession No: NP_005116.1
    RNA Reference Number: NM_005125.1
    OMIM Number: 603864
    Chromosome Location: 11q13
    cDNA size: 825bp
    Vector description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
    
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- Properties
  - Type
    
    cDNAs
    
    Formulation
    
    Lyophilized
    
    Storage
    
    Store the plasmid at -20°C.
    
    Sequence
    
    Nucleotide Sequence: ATGGCTTCGG ATTCGGGGAA CCAGGGGACC CTCTGCACGT TGGAGTTCGC GGTGCAGATG ACCTGTCAGA GCTGTGTGGA CGCGGTGCGC AAATCCCTGC AAGGGGTGGC AGGTGTCCAG GATGTGGAGG TGCACTTGGA GGACCAGATG GTCTTGGTAC ACACCACTCT ACCCAGCCAG GAGGTGCAGG CTCTCCTGGA AGGCACGGGG CGGCAGGCGG TACTCAAGGG CATGGGCAGC GGCCAGTTGC AGAATCTGGG GGCAGCAGTG GCCATCCTGG GGGGGCCTGG CACCGTGCAG GGGGTGGTGC GCTTCCTACA GCTGACCCCT GAGCGCTGCC TCATCGAGGG AACTATTGAC GGCCTGGAGC CTGGGCTGCA TGGACTCCAC GTCCATCAGT ACGGGGACCT TACAAACAAC TGCAACAGCT GTGGGAATCA CTTTAACCCT GATGGAGCAT CTCATGGGGG CCCCCAGGAC TCTGACCGGC ACCGCGGAGA CCTGGGCAAT GTCCGTGCTG ATGCTGACGG CCGCGCCATC TTCAGAATGG AGGATGAGCA GCTGAAGGTG TGGGATGTGA TTGGCCGCAG CCTGATTATT GATGAGGGAG AAGATGACCT GGGCCGGGGA GGCCATCCCT TATCCAAGAT CACAGGGAAC TCCGGGGAGA GGTTGGCCTG TGGCATCATT GCACGCTCCG CTGGCCTTTT CCAGAACCCC AAGCAGATCT GCTCTTGCGA TGGCCTCACC ATCTGGGAGG AGCGAGGCCG GCCCATCGCT GGCAAGGGCC GAAAGGAGTC AGCGCAGCCC CCTGCCCACC TTTGA
    Translation Sequence: MASDSGNQGT LCTLEFAVQM TCQSCVDAVR KSLQGVAGVQ DVEVHLEDQM VLVHTTLPSQ EVQALLEGTG RQAVLKGMGS GQLQNLGAAV AILGGPGTVQ GVVRFLQLTP ERCLIEGTID GLEPGLHGLH VHQYGDLTNN CNSCGNHFNP DGASHGGPQD SDRHRGDLGN VRADADGRAI FRMEDEQLKV WDVIGRSLII DEGEDDLGRG GHPLSKITGN SGERLACGII ARSAGLFQNP KQICSCDGLT IWEERGRPIA GKGRKESAQP PAHL.
    
    * For research use only. Not intended for human, diagnostics or veterinary use.
- Applications
  - Application Description
    
    (1) Centrifuge at 7000rpm for 1 minute. (2) Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

CCS cDNA

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