Name: CCM2 Recombinant Protein
Price: Inquiry

- Overview
  - CCM2 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 311 amino acids (66-353 a.a) and having a molecular mass of 34.3kDa. CCM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Cerebral Cavernous Malformation 2, also known as CCM2 is a piece of the CCM signaling pathway which is a vital regulator of heart and vessel formation as well asintegrity. CCM2 performs through the stabilization of endothelial cell junctions. In addition, CCM2 functions as a scaffold protein for MAP2K3-MAP3K3 signaling. CCM2 plays a key role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock. Mutations in CCM2 result in cerebral cavernous malformations. Multiple transcript variants encoding dissimilar isoforms have been discovered for CCM2.
    
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- Properties
  - Protein Name
    
    Cerebral Cavernous Malformation 2, C7orf22, malcavernin, CerebralCavernous Malformations 2 Protein, Chromosome 7 Open Reading Frame 22, OSM, MGC4067.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greaterthan 90.0% as determined by SDS-PAGE.
    
    Formulation
    
    CCM2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

CCM2 Recombinant Protein

CCM2 Recombinant Protein

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