Name: CAY10603
Price: 292.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively)[1].
    CAY10603 inhibits the proliferation and induces apoptosis of lung adenocarcinoma cells. In addition, CAY10603 works in concert with gefitinib to induce apoptosis in lung adenocarcinoma cell lines, in part due to EGFR instability and EGFR pathway inactivation[2].
    In C57BL/6 mice model of endotoxemia, CAY10603 (intraperitoneal injection, 5 mg/kg, 2h) pretreatment significantly inhibits endotoxin-induced caspase-3 activation and reduces endotoxin-induced pulmonary edema form[3].
    
    [1]. Kozikowski A P, Tapadar S, Luchini D N, et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. Journal of Medicinal Chemistry, 2008, 51(15): 4370-4373.
    [2]. Wang Z, et al. HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma. Oncol Rep, 2016, 36(1): 589-97.
    [3]. Yu J, Ma M, Ma Z, et al. HDAC6 inhibition prevents TNF-α-induced caspase 3 activation in lung endothelial cell and maintains cell-cell junctions. Oncotarget, 2016, 7(34): 54714-54722.
- Properties
  - Alternative Name
    
    tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
    
    CAS Number
    
    1045792-66-2
    
    Molecular Formula
    
    C22H30N4O6
    
    Molecular Weight
    
    446.5
    
    Appearance
    
    A solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    ≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

CAY10603

CAY10603

Background

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