Name: CAMLG Recombinant Protein
Price: Inquiry

- Overview
  - CAMLG Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-189) and having a molecular mass of 23.2kDa. CAMLG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. The immunosuppressant medicine cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) which generally results in T-cell activation. cyclosporin A binds to cyclophilin B and the complex inactivates the main signaling intermediate calcineurin. CAMLG functions in the same way as cyclosporin A. CAMLG binds to cyclophilin B and operates downstream of the TCR and upstream of calcineurin by causing an influx of calcium. CAMLG is an essential membrane protein that takes part in the calcium signal transduction pathway, connecting cyclophilin B to calcium signaling, even when cyclosporine is not present.
    
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- Properties
  - Protein Name
    
    Calcium Modulating Ligand, Calcium-Modulating Cyclophilin Ligand, Calcium-Signal Modulating Cyclophilin Ligand, Cyclophilin B-Binding Protein, CAML.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 90% as determined by SDS-PAGE.
    
    Formulation
    
    The CAMLG solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

CAMLG Recombinant Protein

CAMLG Recombinant Protein

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