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Overview
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Antigen Distribution: CXCR4 is expressed in various organs including ovary, bone marrow, kidney, lung, small intestine, spleen, lymph nodes, brain, stomach, liver, thymus, heart, and pancreas as well as on the surface of endothelial mature and precursor cells and pericytes.
Specificity: 12G5 activity is directed against human CXCR4 (CD184; Fusin)
Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Isotype Control: Mouse IgG2a In Vivo Isotype Control – Low Endotoxin (C1.18.4) [ICH2245]
Endotoxin: <1.0 EU/mg as determined by the LAL method
Aggregation: Aggregation level ≤ 5%Please contact us at for specific academic pricing.
Background
12G5 binds specifically to both human and nonhuman cells that express recombinant CXCR4. 12G5 inhibits CD4-independent infection by some HIV-2 isolates, and preincubating cells with 12G5 abolishes syncytium formation. HIV-2/vcp-infected cells display a marked and selective reduction in 12G5 binding. 12G5 also inhibits induction of cell-to-cell fusion of CXCR4+ RD/CD4 cells by HIV-1 and HIV-2 strains.
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