Name: Bulk anti-Human CD38 antibody (OKT10) - Low Endotoxin
Price: 680.00 USD

- Overview
  - Antigen Distribution: CD38 is present on the surface of immune cells such as CD4+, CD8+, B lymphocytes, natural killer cells, mature lymphocytes, and mature lymphoplasmacytic cells.
    Specificity: Clone OKT10 recognizes an epitope on human CD38.
    Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
    Isotype Control: Mouse IgG1 Isotype Control for In Vivo - Low Endotoxin [HKSP] (ICH2247)
    Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method
    Aggregation: Aggregation level ≤ 5%
    
    Please contact us at for specific academic pricing.
    
    Background
    
    CD38 is a 45kD type II transmembrane glycoprotein that plays a role in the regulation of intracellular Ca2+ by synthesizing and hydrolyzing an intracellular calcium ion mobilizing messenger. CD38 has both extracellular and intracellular functions as indicated by the release of soluble protein and the ability of membrane-bound protein to become internalized. The functional molecule is a dimer that contains the catalytic site in the central portion, and is involved in both extracellular and intracellular functions. CD38 plays a role in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a biomarker to measure the progress of a chronic lymphocytic leukemia in patients. Because CD38 is expressed on mature lymphocytes and lymphoplasmacytic cells, OKT10 can be used to study final B cell maturation. OKT10 reactivity with CD38 occurs in an inversely proportional relationship to the occurrence of Ia-like antigenic expression. Hence, these two antigens can be used as reciprocal complementary reactants for the study of mature B cell malignancies, such as CLL, multiple myeloma, and Waldenström malignancy.
- Properties
  - Host
    
    mouse
    
    Isotype
    
    IgG1
    
    Reactivity
    
    human
    
    Clone
    
    OKT10
    
    Purification
    
    >95% by SDS-PAGE and HPLC
    
    Formulation
    
    This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and azide free
    
    Storage
    
    This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
    
    Molecular Weight
    
    1mg/ml
    
    Regulatory Status
    
    Each investigator should determine their own optimal working dilution for specific applications.
    
    Antigen
    
    (Gene ID:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, ADPRC 1, I-19, NIM-R5)
    
    * Products are for research use only. Not for use in diagnostic or therapeutic procedures.
- Applications
  - Application
    
    Flow cytometry

Bulk anti-Human CD38 antibody (OKT10) - Low Endotoxin

Bulk anti-Human CD38 antibody (OKT10) - Low Endotoxin

Background

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