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Overview
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Reactivity: The monoclonal antibody is directed against the CD7-antigen (3A1-antigen), which is expressed on human T lymphocytes.The monoclonal antibody reacts with the cells of the T lymphocyte linage, with the cells of patients with a Lymphocytic Leukaemia of the T lymphocyte origin, and with the cells of patients with the Sezary Syndrome. Platelets and cells of the B lymphocyte myelocytic and monocytic lineage are found negative. Specificity: Anti-CD7, HIT7 was included in the fifth International Workshops on Human Leucocyte Differentiation Antigens. This antibody reacts with the CD7 antigen, a 40kDa polypeptide. This is the earliest marker antigen expressed in the T cell lineage and is found on T cell precursors in fetal liver and thorax prior to thymic colonization and in bone marrow and the thymus. It is also to be found on a small subpopulation of normal B cells and on malignant B cells.
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