Name: Batimastat (BB-94)
Price: 252.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Batimastat (also known as BB-49), [4-(N-hydroxyamino)-2R-isobutyl-3S-(thiopen-2-ylthiomethyl)-succinyl-L-phenylalanine-N-methylamide, is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). It is a low-molecular-weight (MW = 478) and peptide-like collagen substrate analogue consisting of a peptide backbone and a hydroxamic acid group which bind to MMPs and the catalytically active zinc atom respectively. Batimastat exhibits antineoplastic and antiangiogenic activity in various tumor models, including ovarian carcinoma xegnografts and human colon tumor.
- Properties
  - Alternative Name
    
    Batimastat, BB-94; (2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-2-((thiophen-2-ylthio)methyl)succinamide
    
    CAS Number
    
    130370-60-4
    
    Molecular Formula
    
    C23H31N3O4S2
    
    Molecular Weight
    
    477.64
    
    Appearance
    
    A solid
    
    Purity
    
    97.95%
    
    Solubility
    
    ≥23.88 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    
    Storage
    
    Store at 4°C
    
    * For Research Use Only
- Reference
  - 1. Miri Morgulis, Mark R Winter, et al. "VEGF signaling activates the matrix metalloproteinases, MmpL7 and MmpL5 at the sites of active skeletal growth and MmpL7 regulates skeletal elongation." Dev Biol. 2021 May;473:80-89. PMID:33577829
    2. Chan ZC, Kwan HR, et al. "Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs." Elife. 2020;9:e54379. PMID:32208136
    3. Xi Y, Huang H, et al. "Tissue inhibitor of metalloproteinase 1 suppresses growth and differentiation of osteoblasts and differentiation of osteoclasts by targeting the AKT pathway." Exp Cell Res. 2020;111930. PMID:32113948
    4. Karpova D, Rettig MP, et al. "Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells." J Clin Invest. 2019 May 14;130:2745-2759. PMID:31085833
    5. Clarke C, Gallagher C, et al. "Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq."Biotechnol Bioeng. 2019 Jun;116(6):1556-1562. PMID:30802296
    6. Lin CC, Kurashige M, et al. "A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed." Sci Rep. 2018 Feb 9;8(1):2743. PMID:29426897
    7. Lertudomphonwanit C, Mourya R, et al. "Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia." Sci Transl Med. 2017 Nov 22;9(417). PMID:29167395
    8. Kidacki M, Lehman HL, et al. "p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC." Mol Cancer Res. 2017 Oct;15(10):1398-1409. PMID:28637905
    9. Bao JX, Zhang QF, et al. "Implication of CD38 gene in autophagic degradation of collagen I in mouse coronary arterial myocytes." Front Biosci (Landmark Ed). 2017 Jan 1;22:558-569. PMID:27814632
    10. Zhang K, Liu X, et al. "Targeting TGF-β1 inhibits invasion of anaplastic thyroid carcinoma cell through SMAD2-dependent S100A4-MMP-2/9 signalling." Am J Transl Res. 2016 May 15;8(5):2196-209. PMID:27347327
    11. Werneburg S, Buettner FF, et al. "Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages." Glia.2016 May 9. PMID:27159043

Batimastat (BB-94)

Batimastat (BB-94)

Background

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