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Overview
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Trypsinogen is the precursor form of the pancreatic enzyme trypsin. It is found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen. It is activated by enteropeptidase, which is found in the intestinal mucosa, to form trypsin. Once activated, the trypsin can activate more trypsinogen into trypsin. Trypsin cleaves peptide bond on carboxyl side of basic amino acids. High serum trypsinogen levels are seen in acute pancreatitis, and cystic fibrosis. Determination of urine trypsinogen-2 is also a useful test to detect acute pancreatitis and to evaluate disease severity.
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Overview