Name: Anti-Mouse ICOS In Vivo Antibody - Low Endotoxin (7E.17G9)
Price: 680.00 USD

- Overview
  - Specificity: Anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) recognizes an epitope on Mouse ICOS
    Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
    Isotype Control: Rat IgG2b In Vivo Isotype Control - Low Endotoxin [1-2] (ICH2243)
    Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method
    Aggregation: Aggregation level ≤ 5%
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Inducible co-stimulator (ICOS), also called ALIM and H4, is a homodimeric protein and member of the CD28 family of immune co-stimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. Unlike the constitutively expressed CD28, ICOS has to be de novo induced on the T cell surface, does not up-regulate the production of IL-2, but superinduces the synthesis of IL-10, a B cell-differentiation factor. In vivo, ICOS is highly expressed on tonsillar T cells, which are closely associated with B cells in the apical light zone of germinal centres, the site of terminal B cell maturation. ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses. It is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases.
- Properties
  - Host
    
    rat
    
    Isotype
    
    IgG2b
    
    Reactivity
    
    mouse
    
    Clone
    
    7E.17G9
    
    Purification
    
    >95% by SDS-PAGE and HPLC
    
    Formulation
    
    0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
    
    Storage
    
    anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) is stable when stored at 2-8°C. Do not freeze. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
    
    Molecular Weight
    
    1.0 - 5.0 mg/ml
    
    Regulatory Status
    
    Each investigator should determine their own optimal working dilution for specific applications.
    
    Antigen
    
    (Gene ID:Inducible T-cell costimulator, Icos, Activation-inducible lymphocyte immunomediatory molecule, CD28 and CTLA-4-like protein, CCLP, CD28-related protein 1, CRP-1, Ailim, CD278)
    
    * Products are for research use only. Not for use in diagnostic or therapeutic procedures.
- Applications
  - Application
    
    WB; Blocking; Functional Assays; Flow Cytometry

Anti-Mouse ICOS In Vivo Antibody - Low Endotoxin (7E.17G9)

Anti-Mouse ICOS In Vivo Antibody - Low Endotoxin (7E.17G9)

Background

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