Name: Anti-HP-Alpha antibody
Price: 224.00 USD

Overview
- HP-1 alpha is a protein encoded by the CBX5 gene which is approximately 22, 2 kDa. HP-1 alpha is localised to the nucleus. It is involved in chromatin regulation and acetylation, E2F mediated regulation of DNA replication and aurora B signalling. It is a highly conserved non-histone protein that falls under the heterochromatin protein family. It has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins. It is also involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. HP-1 alpha is expressed in the liver, nervous system, kidney, eye and intestine. Mutations in the CBX5 gene may result in Reynolds syndrome. STJ98895 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody detects endogenous HP-1 alpha protein.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant peptide derived from HP-1alpha.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha (Gene ID:23468; UniProt:P45973)
  
  * For research use only