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Overview
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FGF-13 is a protein encoded by the FGF13 gene which is approximately 27, 5 kDa. FGF-13 is localised to the cell membrane, cytoplasm and nucleus. It is involved in apoptotic pathways, GPCR pathway, TGF-Beta pathway and ERK signalling. It is a microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. It also plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. FGF-13 is expressed in the nervous system, eye, kidney, skin and lung. Mutations in the FGF13 gene may result in Borjeson-Forssman-Lehmann syndrome and Wildervanck syndrome. STJ93061 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of FGF-13 protein.
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