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Overview
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Beta actin is a cytoskeletal protein of the actin family, which is approximately 41, 7 kDa and localised to the cytoplasm. It is encoded by the ACTB gene and is involved in pathways such as blood-brain barrier and immune cell transmigration, regulation of actin cytoskeleton by Rho GTPases and development Slit-Robo signalling. Beta actin is one of 3 main groups of actin isoforms in vertebrates namely for which alpha and gamma actins are the other two. Beta actin is a highly conserved proteins that is involved in various types of internal cell motility and are the major constituent of microfilaments and it is ubiquitously expressed in all eukaryotic cells. Mutations in the ACTB gene can result in a form of juvenile-onset dystonia, which is defined by the presence of sustained involuntary muscle contraction-often leading to abnormal postures. Another disease, Baraitser-Winter syndrome 1, is also caused by ACTB mutation. This is rare developmental disorder that causes postnatal short stature and microcephaly, intellectual disability, seizures, and hearing loss. STJ96930 was developed to target endogenous beta actin, and is affinity-purified from mouse ascites by affinity-chromatography.
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