Name: AMPK alpha2 Polyclonal Antibody
Price: 326.00 USD

Overview
- Calculated MW: 15 kDa
  Observed MW: 15 kDa
  
  Please contact us at for specific academic pricing.
  
  Background
  
  The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant Rat Ampk2 protein expressed by E.coli
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH 7.4
  
  Storage
  
  Store at -20°C Valid for 12 months. Avoid freeze-thaw cycles.
  
  Concentration
  
  1 mg/mL
  
  Antigen
  
  5'-AMP-activated protein kinase catalytic subunit alpha-2, AAPK2, ACACA kinase, Acetyl-CoA carboxylase kinase, AMPK alpha 2 chain, AMPK subunit alpha-2, AMPK2, AMPKa2, AMPKalpha2, HMGCR kinase, Hydroxymethylglutaryl-CoA reductase kinase, PRKAA, PRKAA2, Protein kinase AMP activated alpha 2 catalytic subunit, Protein kinase AMP activated catalytic subunit alpha 2 (UniProt:Q09137)
  
  * For reference only.