Acetaminophen

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with IC50 of 25.8 μM, It is a widely used antipyretic analgesic[1].
    Paracetamol (50 mM) significantly reduces cell viability. But co-treatment with acetaminophen and HV110 can significantly increase cell viability[2].
    Paracetamol (250 mg / kg) reduces glutathione levels and glutathione peroxidase activity in mice, and induces mast cell death and hypertrophy in primary mouse liver cells The inhibitor ferrostatin-1 can block this effect. Paracetamol has analgesic and antipyretic effects in animal models.
    
    [1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man, 2008, 22(2): 383-90.
    [2]. Dini M, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol, 2017, 8: 594.
    [3]. Lőrincz T, Jemnitz K, Kardon T, et al. Ferroptosis is Involved in Acetaminophen Induced Cell Death. Pathology & Oncology Research, 2015, 21(4): 1115-1121.
- Properties
  - Alternative Name
    
    (Z)-N-(4-hydroxyphenyl)acetimidic acid
    
    CAS Number
    
    103-90-2
    
    Molecular Formula
    
    C8H9NO2
    
    Molecular Weight
    
    151.16
    
    Appearance
    
    A solid
    
    Purity
    
    99.96%
    
    Solubility
    
    insoluble in H2O; ≥29.4 mg/mL in EtOH; ≥7.56 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Acetaminophen

Background

We Also Recommend

Iohexol

Ramosetron Hydrochloride

Taltirelin