6xHis-Ube2E1 (UbcH6)

- Overview
  - Ube2E1 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2E1 was found to locate in the nucleus. It, along with Ube2D1, is known to complex with the E3 ligase Ro52 to ubiquitinate interferon regulatory transcription factors IRF3 and IRF8. Ube2E1 can also complex with a Ub ligase called RING105 to ubiquitinate a tumor suppressor known as tumor – suppressing subchromosomal transferable fragment cDNA (TSSC5).
    
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- Properties
  - Protein Name
    
    UBCH6
    
    Source
    
    Bacterial recombinant
    
    Formulation
    
    20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
    
    Storage
    
    Store at -80°C; avoid multiple freeze-thaw cycles
    
    Concentration
    
    See tube label
    
    Molecular Weight
    
    21.4 kDa
    
    Sequence
    
    NCBI RefSeq: NM_003341
    
    * Research Use Only