Name: 6,7-Dimethyltetrahydropterin (hydrochloride)
Price: 222.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    IC50: 76-112 μM for GTP cyclohydrolase I 6,7-Dimethyltetrahydropterin is a GTP cyclohydrolase I inhibitor. GTP cyclohydrolase I catalyzes the formation of D-erythro-7,8-dihydroneopterin (dihydroneopterin) triphosphate and formate from GTP. Dihydroneopterin triphosphate has been identified as a critical intermediate in the biosynthesis of folic acid, pteridines in insects and amphibians, and tetrahydrobiopterin. Tetrahydrobiopterin is the obligatory cofactor for tyrosine and tryptophan hydroxylase, which are rate-limiting enzymes for biogenic amine synthesis. Tetrahydrobiopterin is the cofactor for phenylalanine hydroxylase as well, which converts Lphenylalanine to L-tyrosine. In vitro: Previous study identified 6,7-dimethyltetrahydropterin as a noncompetitive inhibitor of GTP cyclohydrolase. However, no substrate inhibition of the enzyme was detected 1mM GTP, which is about 8-fold the Km value of the enzyme [1]. Another study found that phenylalanine hydroxylase could be inhibited by 6,7-dimethyltetrahydropterin, its cofactor. The rate of inactivation, which was irreversible, increased with the concentration of 6,7-dimethyltetrahydropterin. Moreover, 6,7-dimethyltetrahydropterin was found to be unstable when the solution was exposed to air but was stabilized by dithiothreitol the aerobic oxidation of which was significantly accelerated by 6,7-dimethyltetrahydropterin [2]. In vivo: Up to now, there is no animal in vivo data reported.Clinical trial: So far, no clinical study has been conducted.
    
    [1] Shen, R. ,Alam, A. and Zhang, Y. Inhibition of GTP cyclohydrolase I by pterins. Biochimica et Biophysica Acta 965, 9-15 (1988).
    [2] Jakubovic A, Woolf LI, Chan-Henry E. The inactivation of phenylalanine hydroxylase by 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine and the aerobic oxidation of the latter. The effects of catalase, dithiothreitol and reduced nicotinamide-adenine dinucleotide. Biochem J. 1971 Nov;125(2):563-8.
- Properties
  - Alternative Name
    
    2-amino-5,6,7,8-tetrahydro-cis-6,7-dimethyl-4(1H)-pteridinone, hydrochloride
    
    CAS Number
    
    167423-51-0
    
    Molecular Formula
    
    C8H13N5O·HCl
    
    Molecular Weight
    
    231.7
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

6,7-Dimethyltetrahydropterin (hydrochloride)

6,7-Dimethyltetrahydropterin (hydrochloride)

Background

We Also Recommend

2-Hydroxyestradiol

ML-193

RO8191