Name: 2-Hydroxypropyl-β-cyclodextrin
Price: 180.00 USD

- Overview
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    Background
    
    2-Hydroxypropyl-β-cyclodextrin is a cyclic oligosaccharide containing 7 glucopyranose units, with an average of one hydroxypropyl group per unit. The circular arrangement of the glucose units forms a torus-shaped ring configuration, and CH2 groups and ether linkages of the molecule face the hollow interior of the configuration, which leads to a nonpolar cavity and a polar exterior. When a compound with appropriate geometry and 2-hydroxypropyl-β-cyclodextrin are in the same solution, the nonpolar aromatic parts of that compound tend to interact with the nonpolar interior of the 2-hydroxypropyl-β-cyclodextrin molecule. This complexation isolates the aromatic parts of that compound from the water, thereby increasing its aqueous solubility. 2-Hydroxypropyl-β-cyclodextrin has been widely used in improving the aqueous solubility of a variety of compounds, especially those containing a phenyl group, a group encompassing many drugs.
    
    1. Katageri, A.R., and Sheikh, M.A. Cyclodextrin a gift to pharmaceutical world review. International Research Journal of Pharmacy, 2012, 3(1): 52-56.
    2. Shewale BD, Sapkal NP, Raut NA, et al. Effect of hydroxylpropyl-β-cyclodextrin on solubility of carvedilol. Indian Journal of Pharmaceutical Sciences, 2008, 70(2): 255-257.
- Properties
  - Categories
    
    A cyclic oligosaccharide widely used to improve the aqueous solubility of a variety of compounds
    
    CAS Number
    
    128446-35-5
    
    Molecular Formula
    
    C63H112O42
    
    Molecular Weight
    
    1541.55
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    95.00%
    
    Solubility
    
    ≥24.9 mg/mL in EtOH; ≥42 mg/mL in DMSO; ≥47 mg/mL in H2O
    
    Storage
    
    Store at RT
    
    SMILES
    
    O[[email protected]@H]1[[email protected]](O[[email protected]@H]2[[email protected]@H](O)[[email protected]](O)[[email protected]](O[[email protected]@H]3[[email protected]@H](O)[[email protected]](O)[[email protected]](O[[email protected]@H]4[[email protected]@H](O)[[email protected]](O)[[email protected]](O[[email protected]@H]5[[email protected]@H](O)[[email protected]](O)[[email protected]](O[[email protected]@H]6[[email protected]@H](O)[[email protected]](O)[[email protected]](O[[email protected]@H]7[[email protected]@H](O)[[email protected]](O)[[email protected]]8O[[email protected]]7COCC(O)C)O[[email protected]]6COCC(O)C)O[[email protected]]5COCC(C)O)O[[email protected]]4
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

2-Hydroxypropyl-β-cyclodextrin

2-Hydroxypropyl-β-cyclodextrin

Background

Documents

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