Name: 2-fluoro Palmitic Acid
Price: 265.00 USD

- Overview
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    Background
    
    2-fluoropalmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase [1]. The length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-CoA synthetases (ACS). Mammalian long-chain acyl-CoA synthetases (ACSL) activate fatty acids with chain lengths of 12 to 20 carbon atoms. The long-chain acyl-CoA synthetase mRNA is expressed virtually in heart, liver, and epididymal adipose tissues and, to a much lesser extent, in brain, small intestine, and lung [2]. Palmitic acid was a selective cytotoxic substance extracted from the marine algal. At concentrations ranging from 12.5 to 50 μg/ml, palmitic acid showed selective cytotoxicity to human leukemic cells, but no cytotoxicity to normal HDF cells. Palmitic acid (50 μg/ml) induced apoptosis in the human leukemic cell line MOLT-4. Palmitic acid also showed in vivo antitumor activity in mice [3]. 2-fluoropalmitic acid showed an inhibitory effect on sphingosine biosynthesis and long-chain acyl-CoA synthetase with an IC50 value of 0.2 mM [1].
    
    [1] Soltysiak R M, Matsuura F, Bloomer D, et al. d, l-α-fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells[J]. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism, 1984, 792(2): 214-226.
    [2] Suzuki H, Kawarabayasi Y, Kondo J, et al. Structure and regulation of rat long-chain acyl-CoA synthetase[J]. Journal of Biological Chemistry, 1990, 265(15): 8681-8685.
    [3] Harada H, Yamashita U, Kurihara H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga[J]. Anticancer research, 2001, 22(5): 2587-2590.
- Properties
  - Alternative Name
    
    2-fluorohexadecanoic acid
    
    CAS Number
    
    16518-94-8
    
    Molecular Formula
    
    C16H31FO2
    
    Molecular Weight
    
    274.4
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only