Name: 1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucose
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- Overview
  - Peracetylated 2-fluoro-L-fucose is the acetylated form of 2-deoxy-2-fluoro-L-fucose which is a potent inhibitor of protein fucosylation. It exhibits improved cell permeability and is rapidly deacetylated into its active form, inside the cell. It is metabolised inside the cell into a corresponding donor substrate analogue of GDP-fucose or GDP-2FF, via the salvage pathway. GDP-2FF accumulates in the cell causing a shutdown of de novo pathway which leads to the desired fucosylation inhibition. The addition of 100 uM peracetylated-2-fluoro-L-fucose to plants severely inhibits root growth by 95% compared to an untreated plant, and is more potent compared to 2-fluoro-L-fucose.
    
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- Properties
  - Alternative Name
    
    Peracetylated 2-fluoro 2-deoxy-L-fucose
    
    CAS Number
    
    188783-78-0
    
    Molecular Formula
    
    C12H17FO7
    
    Molecular Weight
    
    292.26 g/mol
    
    MDL Number
    
    MFCD22124251
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Okeley et al (2013). Development of orally active inhibitors of protein and cellular fucosylation. Proceedings of the National Academy of Sciences of the United States of America. 110:5404-5409
    Villalobos et al (2015). 2-Fluoro-L-Fucose Is a Metabolically Incorporated Inhibitor of Plant Cell Wall Polysaccharide Fucosylation. Public Library of Science ONE. 10:1-16
    Zhou et al (2017). Inhibition of fucosylation by 2-fuorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation. Scientific Reports. 7:11563

MSDS

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Specification

1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucose

1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucose

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