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Overview
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Threonine324/serine327 (T324/S327) is a major phosphorylation site of the C5a1 receptor. The pT324/pS327-C5a1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T324/S327 phosphorylation is a key regulator of C5a1 desensitization, β-arrestin recruitment and internalization. The pT324/pS327-C5a1 antibody can by used for detection of the subcellular location of phosphorylated C5a1 receptors by immunocytochemistry.
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