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Overview
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Serine412 (S412) is a major phosphorylation site of the β1 adrenoceptor. The pS412-β1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S412 phosphorylation is primarily mediated by GRKs and is a key regulator of β1 desensitization, β-arrestin recruitment and internalization.
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