Glucose (Glc) Colorimetric/Fluorometric Assay kit

Glucose (C6H12O6) is the most abundant carbohydrate, which belongs to the group of monosaccharide (simple sugars). It is an aldose, a hexose, and a reducing sugar. The D‐Glucose, also known as dextrose, is a dextrorotatory compound (i.e. rotating polarized light clockwise) that widely exists in nature, as opposed to the L-Glucose isomer which rarely occurs.All living organisms can use Glucose as a major source of energy to produce adenosine triphosphate (ATP) for their biological and molecular activities and multiple cellular functions. In other words, most energy in biological system is generated through aerobic cellular respiration of carbohydrate and Glucose. Reduced energy levels threaten cellular homeostasis and integrity, as impaired energy metabolism may trigger apoptosis (programmed cell death), oxidative damage, excitotoxicity and impeded mitochondrial DNA repair.A serious fall in blood Glucose can be characterized by metabolic dysfunction, neuroglycopenia, seizure, and death. A persistent elevation in blood Glucose leads to “Glucose toxicity.” Glucose toxicity contributes to pancreatic ß-cell dysfunction and the pathology grouped together as complications of diabetes. Estrogen‐induced signaling pathways in hippocampal and cortical neurons involve the mitochondria to enhance mitochondrial function and to sustain aerobic glycolysis and citric acid cycle oxidative phosphorylation and ATP generation.

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