Name: AF/LE Purified Anti-Mouse CD274/PD-L1 Monoclonal Antibody
Price: 258.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
- Properties
  - Host
    
    rat
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG2b kappa
    
    Reactivity
    
    mouse
    
    Formulation
    
    0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.
    
    Storage
    
    Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
    
    Concentration
    
    0.2 mg/mL
    
    Antigen
    
    B7-H1; PD-L1; Programmed cell death ligand 1; B7 homolog 1; B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1 (Gene ID:60533; UniProt:Q9EP73)
    
    * For research use only.
- Applications
  - Application
    
    Flow Cytometry; IHC; IF; Block

AF/LE Purified Anti-Mouse CD274/PD-L1 Monoclonal Antibody

AF/LE Purified Anti-Mouse CD274/PD-L1 Monoclonal Antibody

Background

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