Anti-GP6 Monoclonal Antibody (5H12)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC383	Anti-GP6 Antibody (5H12)	Human IgG1		None	$460	4-6 weeks	Add
ASPC383-1	Anti-GP6 Antibody (5H12), Fab fragment	Human Fab	His tag	None	$460	In stock	Add
ASPC383-P	Anti-GP6 Antibody (5H12), PE	Human IgG1		PE	$1,180	4-6 weeks	Add
ASPC383-A	Anti-GP6 Antibody (5H12), APC	Human IgG1		APC	$980	4-6 weeks	Add
ASPC383-H	Anti-GP6 Antibody (5H12), HRP	Human IgG1		HRP	$600	4-6 weeks	Add
ASPC383-B	Anti-GP6 Antibody (5H12), Biotin	Human IgG1		Biotin	$680	4-6 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC383

Anti-GP6 Antibody (5H12)

Human IgG1

None

$460

4-6 weeks

Add

ASPC383-1

Anti-GP6 Antibody (5H12), Fab fragment

Human Fab

His tag

None

$460

In stock

Add

ASPC383-P

Anti-GP6 Antibody (5H12), PE

Human IgG1

$1,180

4-6 weeks

Add

ASPC383-A

Anti-GP6 Antibody (5H12), APC

Human IgG1

APC

$980

4-6 weeks

Add

ASPC383-H

Anti-GP6 Antibody (5H12), HRP

Human IgG1

HRP

$600

4-6 weeks

Add

ASPC383-B

Anti-GP6 Antibody (5H12), Biotin

Human IgG1

Biotin

$680

4-6 weeks

Add

Anti-GP6 Monoclonal Antibody (5H12)
- Product Description:
  
  The Anti-GP6 antibody is a human monoclonal antibody recommended for use in ELISA, western blot and other applications. This antibody specifically targets GP6 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot
  
  Target:
  
  GP6
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human GPVI.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  5H12
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-GP6 Monoclonal Antibody (5H12) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

GP6

Protein Name

Platelet glycoprotein VI

Introduction

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative Names

GP6; glycoprotein VI (platelet); GPIV; GPVI; BDPLT11; platelet glycoprotein VI; glycoprotein 6

Gene ID

51206

UniProt

Q9HCN6

Related Disease

Bleeding disorder, platelet-type, 11 (BDPLT11)

Tissue Specificity

Megakaryocytes and platelets.

Cell Line Specificity

Cancer enhanced

Function

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

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