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Anti-HLA-DQB1 Monoclonal Antibody (16H12)
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Product Description:The Anti-HLA-DQB1 antibody is a human monoclonal antibody recommended for use in ELISA, western blot, dot blot, functional assay and other applications. This antibody specifically targets HLA-DQB1 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western Blot, Dot Blot, Functional AssayTarget:HLA-DQB1Target Species:HumanSpecificity:This antibody reacts with human HLA-DQB1.Clonality:MonoclonalClone ID:16H12Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-HLA-DQB1 Monoclonal Antibody (16H12) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
HLA-DQB1
Protein Name
HLA class II histocompatibility antigen, DQ beta 1 chain
Introduction
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.
Alternative Names
HLA-DQB1; major histocompatibility complex, class II, DQ beta 1; HLA-DQB; HLA class II histocompatibility antigen, DQ beta 1 chain; MHC DQ beta; MHC class2 antigen; lymphocyte antigen; MHC class II antigen DQB1; MHC class II DQ beta chain
Gene ID
UniProt
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