Anti-ITGAV Monoclonal Antibody (17E6)

Subcat	Description	Isotype	Conjugate	Price
ASPC1218	Anti-ITGAV Antibody (17E6)	Human IgG1, Kappa	None	$460	Add
ASPC1218-A	Anti-ITGAV Antibody (17E6), APC	Human IgG1, Kappa	APC	$980	Add
ASPC1218-B	Anti-ITGAV Antibody (17E6), Biotin	Human IgG1, Kappa	Biotin	$680	Add
ASPC1218-H	Anti-ITGAV Antibody (17E6), HRP	Human IgG1, Kappa	HRP	$600	Add
ASPC1218-P	Anti-ITGAV Antibody (17E6), PE	Human IgG1, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1218

Anti-ITGAV Antibody (17E6)

Human IgG1, Kappa

None

$460

Add

ASPC1218-A

Anti-ITGAV Antibody (17E6), APC

Human IgG1, Kappa

APC

$980

Add

ASPC1218-B

Anti-ITGAV Antibody (17E6), Biotin

Human IgG1, Kappa

Biotin

$680

Add

ASPC1218-H

Anti-ITGAV Antibody (17E6), HRP

Human IgG1, Kappa

HRP

$600

Add

ASPC1218-P

Anti-ITGAV Antibody (17E6), PE

Human IgG1, Kappa

$1,180

Add

Anti-ITGAV Monoclonal Antibody (17E6)
- Product Description:
  
  The Anti-ITGAV antibody is a human monoclonal antibody recommended for use in flow cytometry, enzyme-linked immunosorbent assay, immunoprecipitation and other applications. This antibody specifically targets ITGAV and demonstrates reactivity with human.
  
  Applications:
  
  Flow Cytometry, Enzyme-Linked Immunosorbent Assay, Immunoprecipitation
  
  Source:
  
  Human
  
  Target:
  
  ITGAV
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human ITGAV.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  17E6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ITGAV Monoclonal Antibody (17E6) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ITGAV

Protein Name

Integrin alpha-V

Introduction

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

Alternative Names

CD51; MSK8; VNRA; VTNR

Gene ID

3685

UniProt

P06756

Cell Line Specificity

Cancer enhanced

Function

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling.

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