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Anti-TAGLN Monoclonal Antibody (SAIC-33B-129)
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Product Description:The Anti-TAGLN antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, western blot and other applications. This antibody specifically targets TAGLN and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western BlotTarget:TAGLNTarget Species:HumanSpecificity:This antibody reacts with Human TAGLN.Immunogen:Transgelin KLH peptide.Clonality:MonoclonalClone ID:SAIC-33B-129Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-TAGLN Monoclonal Antibody (SAIC-33B-129) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
TAGLN
Protein Name
Transgelin
Introduction
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.
Alternative Names
SM22; SMCC1; WS3-10; TAGLN
Gene ID
UniProt
Subcellular Location
Cytoplasm
Cell Line Specificity
Cancer enhanced
Function
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
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