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Anti-CD8A Monoclonal Antibody (2.43)
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Product Description:The 2.43 antibody is a monoclonal antibody that specifically recognizes mouse CD8. When used in vivo, the 2.43 antibody can deplete CD8+ T-cells.Applications:Blocking, Immunoprecipitation, Flow Cytometry, Immunofluorescence, Western Blot, DepletionSource:RatTarget:CD8ATarget Species:MouseSpecificity:Mouse Cd8aImmunogen:CTL clone L3 cells of mouse originClonality:MonoclonalClone ID:2.43Isotype:Chimeric (Rat/Mouse) IgG2b, KappaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CD8A Monoclonal Antibody (2.43) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
Cd8a
Protein Name
T-cell surface glycoprotein CD8 alpha chain
Molecular Family
CD Molecules
Introduction
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein.
Alternative Names
Cd8a; T-cell surface glycoprotein CD8 alpha chain; Lyt-2; Lyt2
Gene ID
UniProt
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